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李翔

助理教授

xianglibp@xmu.edu.cn

物理大楼361

个人主页:http://www.shuai-lab.com/

研究领域 生命系统通常都是开放、远离平衡态的复杂系统,同样遵循基本的物理学定律。我们主要从事物理学与生命科学交叉领域的研究,致力于运用复杂系统、统计力学以及能量景观和耗散等方法,通过揭示细胞信号网络动力学与非平衡统计物理特性,为对生命系统功能的理解及调控提供理论基础,为推动人类健康的策略与生命科学的发展提供交叉学科学术视野。

教育和工作经历
2022.07 - 至今          厦门大学物理科学野草伊园甸973乳液,助理教授
2016.07 - 2022.06       厦门大学生命科学学院,博士后
2013.09 - 2016.06       厦门大学物理科学野草伊园甸973乳液,博士
代表性文章或专著
(#:共同一作; *:通讯作者)
[1]. Jin, J., Xu, F., Liu, Z., Shuai, J., & Li, X.* (2024). Quantifying the underlying landscape, entropy production and biological path of the cell fate decision between apoptosis and pyroptosis. Chaos, Solitons & Fractals, 178, 114328.
[2]. Li, X., Wu, M.*, & Shuai, J.* (2023). Clovibactin: a revolutionary antibiotic unleashing lethal efficacy against pathogens with little drug resistance. Science Bulletin, in press.
[3]. Jin, J., Xu, F., Liu, Z., Qi, H., Yao, C., Shuai, J., & Li, X.* (2023). Biphasic amplitude oscillator characterized by distinct dynamics of trough and crest. Physical Review E, 108(6), 064412.
[4]. Yao, C., Sun, J., Jin, J., Shuai, J., Li, X.*, Yao, Y.*, & Xu, X. (2023). The power law statistics of the spiking timing in a neuronal network. Chaos, Solitons & Fractals, 172, 113598.
[5]. He, Q.#, Zhong, C. Q.#, Li, X.#, Guo, H., Li, Y., Gao, M., ... & Han, J.* (2023). Dear-DIAXMBD: Deep Autoencoder Enables Deconvolution of Data-Independent Acquisition Proteomics. Research, 6, 0179.
[6]. Xu, F., Miao, D., Li, W., Jin, J., Liu, Z., Shen, C., ... & Li, X.* (2023). Specificity and competition of mRNAs dominate droplet pattern in protein phase separation. Physical Review Research, 5(2), 023159.
[7]. Hu, H., Feng, Z., Shuai, X. S., Lyu, J., Li, X.*, Lin, H.*, & Shuai, J. (2023). Identifying SARS-CoV-2 infected cells with scVDN. Frontiers in Microbiology, 14.
[8]. Qu, J., Shao, C., Ying, Y., Wu, Y., Liu, W., Tian, Y., Li, X.*, Yu, Z.*, & Shuai, J. (2022). The spring-like effect of microRNA-31 in balancing inflammatory and regenerative responses in colitis. Frontiers in Microbiology, 13, 1089729.
[9]. Li, X.*, Zhang, P., Yin, Z., Xu, F., Yang, Z. H., Jin, J., ... & Shuai, J.* (2022). Caspase-1 and Gasdermin D afford the optimal targets with distinct switching strategies in NLRP1b Inflammasome-induced cell death. Research, 2022.
[10]. Yao, C., Xu, F., Shuai, J., & Li, X.* (2022). Temperature-optimized propagation of synchronous firing rate in a feed-forward multilayer neuronal network. Physica A: Statistical Mechanics and its Applications, 596, 127139.
[11]. Chen, X., Zhu, R., Zhong, J., Ying, Y., Wang, W., Cao, Y., Cai, H., Li, X., Shuai, J., & Han, J. (2022). Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death. Nature Cell Biology, 24(4), 471-482.
[12]. Zhu, L., Li, X.*, Xu, F., Yin, Z., Jin, J., Liu, Z., ... & Shuai, J.* (2022). Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis. Chaos, Solitons & Fractals, 155, 111724.
[13]. Li, X.#, Zhong, C. Q.#, Wu, R.#, Xu, X., Yang, Z. H., Cai, S., ... & Han, J.* (2021). RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes. Protein & Cell, 12(11), 858-876.
[14]. Li, X., Jin, J., Zhang, X., Xu, F., Zhong, J., Yin, Z., ... & Shuai, J.* (2021). Quantifying the optimal strategy of population control of quorum sensing network in Escherichia coli. Npj Systems Biology and Applications, 7(1), 35.
[15]. Yin, Z., Zhang, P. P., Xu, F., Liu, Z., Zhu, L., Jin, J., ... & Li, X.* (2021). Cell death modes are specified by the crosstalk dynamics within pyroptotic and apoptotic signaling. Chaos: An Interdisciplinary Journal of Nonlinear Science, 31(9).
[16]. Xu, F., Yin, Z., Zhu, L., Jin, J., He, Q., Li, X.*, & Shuai, J. (2021). Oscillations governed by the incoherent dynamics in necroptotic signaling. Frontiers in Physics, 9, 726638.
[17]. Li, X., Zhong, C. Q., Yin, Z., Qi, H., Xu, F., He, Q., & Shuai, J. (2020). Data-driven modeling identifies TIRAP-independent MyD88 activation complex and myddosome assembly strategy in LPS/TLR4 signaling. International Journal of Molecular Sciences, 21(9), 3061.
[18]. Li, X., Wu, Y., Gao, X., Cai, M., & Shuai, J.* (2018). Wave failure at strong coupling in intracellular C a 2+ signaling system with clustered channels. Physical Review E, 97(1), 012406.
[19]. Zhang, J.#, Li, X.#, Liang, L., Huang, S., & Zhang, H. (2013). Effects of external stimuli on the pacemaker function of the sinoatrial node in sodium channel gene mutations models. Science China Life Sciences, 56, 818-822.
科研基金及项目
福建省自然科学基金青年创新项目,2023-08至2026-07,主持
厦门大学校长基金,2023-01至2025-12,主持
国家自然科学基金青年基金,2018-01至2020-12,主持
中国博士后科学基金面上项目,2016-01⾄2019-12,主持
国家自然科学基金重大项目,2021-01至2025-12,主要参与人
国家科技部重大项目,2021-12 至2026-11,主要参与人
招生方向
理论物理、凝聚态物理、生物物理、非平衡统计物理
任教课程
大学物理实验、基础物理与交叉学科前沿
姓名 李翔 职称职务 助理教授
邮箱 xianglibp@xmu.edu.cn 办公室 物理大楼361
电话 个人主页 http://www.shuai-lab.com/
其他信息 研究方向岗位职责 生命系统通常都是开放、远离平衡态的复杂系统,同样遵循基本的物理学定律。我们主要从事物理学与生命科学交叉领域的研究,致力于运用复杂系统、统计力学以及能量景观和耗散等方法,通过揭示细胞信号网络动力学与非平衡统计物理特性,为对生命系统功能的理解及调控提供理论基础,为推动人类健康的策略与生命科学的发展提供交叉学科学术视野。
教育和工作经历 2022.07 - 至今          厦门大学物理科学野草伊园甸973乳液,助理教授
2016.07 - 2022.06       厦门大学生命科学学院,博士后
2013.09 - 2016.06       厦门大学物理科学野草伊园甸973乳液,博士
代表性文章或专著 (#:共同一作; *:通讯作者)
[1]. Jin, J., Xu, F., Liu, Z., Shuai, J., & Li, X.* (2024). Quantifying the underlying landscape, entropy production and biological path of the cell fate decision between apoptosis and pyroptosis. Chaos, Solitons & Fractals, 178, 114328.
[2]. Li, X., Wu, M.*, & Shuai, J.* (2023). Clovibactin: a revolutionary antibiotic unleashing lethal efficacy against pathogens with little drug resistance. Science Bulletin, in press.
[3]. Jin, J., Xu, F., Liu, Z., Qi, H., Yao, C., Shuai, J., & Li, X.* (2023). Biphasic amplitude oscillator characterized by distinct dynamics of trough and crest. Physical Review E, 108(6), 064412.
[4]. Yao, C., Sun, J., Jin, J., Shuai, J., Li, X.*, Yao, Y.*, & Xu, X. (2023). The power law statistics of the spiking timing in a neuronal network. Chaos, Solitons & Fractals, 172, 113598.
[5]. He, Q.#, Zhong, C. Q.#, Li, X.#, Guo, H., Li, Y., Gao, M., ... & Han, J.* (2023). Dear-DIAXMBD: Deep Autoencoder Enables Deconvolution of Data-Independent Acquisition Proteomics. Research, 6, 0179.
[6]. Xu, F., Miao, D., Li, W., Jin, J., Liu, Z., Shen, C., ... & Li, X.* (2023). Specificity and competition of mRNAs dominate droplet pattern in protein phase separation. Physical Review Research, 5(2), 023159.
[7]. Hu, H., Feng, Z., Shuai, X. S., Lyu, J., Li, X.*, Lin, H.*, & Shuai, J. (2023). Identifying SARS-CoV-2 infected cells with scVDN. Frontiers in Microbiology, 14.
[8]. Qu, J., Shao, C., Ying, Y., Wu, Y., Liu, W., Tian, Y., Li, X.*, Yu, Z.*, & Shuai, J. (2022). The spring-like effect of microRNA-31 in balancing inflammatory and regenerative responses in colitis. Frontiers in Microbiology, 13, 1089729.
[9]. Li, X.*, Zhang, P., Yin, Z., Xu, F., Yang, Z. H., Jin, J., ... & Shuai, J.* (2022). Caspase-1 and Gasdermin D afford the optimal targets with distinct switching strategies in NLRP1b Inflammasome-induced cell death. Research, 2022.
[10]. Yao, C., Xu, F., Shuai, J., & Li, X.* (2022). Temperature-optimized propagation of synchronous firing rate in a feed-forward multilayer neuronal network. Physica A: Statistical Mechanics and its Applications, 596, 127139.
[11]. Chen, X., Zhu, R., Zhong, J., Ying, Y., Wang, W., Cao, Y., Cai, H., Li, X., Shuai, J., & Han, J. (2022). Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death. Nature Cell Biology, 24(4), 471-482.
[12]. Zhu, L., Li, X.*, Xu, F., Yin, Z., Jin, J., Liu, Z., ... & Shuai, J.* (2022). Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis. Chaos, Solitons & Fractals, 155, 111724.
[13]. Li, X.#, Zhong, C. Q.#, Wu, R.#, Xu, X., Yang, Z. H., Cai, S., ... & Han, J.* (2021). RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes. Protein & Cell, 12(11), 858-876.
[14]. Li, X., Jin, J., Zhang, X., Xu, F., Zhong, J., Yin, Z., ... & Shuai, J.* (2021). Quantifying the optimal strategy of population control of quorum sensing network in Escherichia coli. Npj Systems Biology and Applications, 7(1), 35.
[15]. Yin, Z., Zhang, P. P., Xu, F., Liu, Z., Zhu, L., Jin, J., ... & Li, X.* (2021). Cell death modes are specified by the crosstalk dynamics within pyroptotic and apoptotic signaling. Chaos: An Interdisciplinary Journal of Nonlinear Science, 31(9).
[16]. Xu, F., Yin, Z., Zhu, L., Jin, J., He, Q., Li, X.*, & Shuai, J. (2021). Oscillations governed by the incoherent dynamics in necroptotic signaling. Frontiers in Physics, 9, 726638.
[17]. Li, X., Zhong, C. Q., Yin, Z., Qi, H., Xu, F., He, Q., & Shuai, J. (2020). Data-driven modeling identifies TIRAP-independent MyD88 activation complex and myddosome assembly strategy in LPS/TLR4 signaling. International Journal of Molecular Sciences, 21(9), 3061.
[18]. Li, X., Wu, Y., Gao, X., Cai, M., & Shuai, J.* (2018). Wave failure at strong coupling in intracellular C a 2+ signaling system with clustered channels. Physical Review E, 97(1), 012406.
[19]. Zhang, J.#, Li, X.#, Liang, L., Huang, S., & Zhang, H. (2013). Effects of external stimuli on the pacemaker function of the sinoatrial node in sodium channel gene mutations models. Science China Life Sciences, 56, 818-822.
科研基金及项目 福建省自然科学基金青年创新项目,2023-08至2026-07,主持
厦门大学校长基金,2023-01至2025-12,主持
国家自然科学基金青年基金,2018-01至2020-12,主持
中国博士后科学基金面上项目,2016-01⾄2019-12,主持
国家自然科学基金重大项目,2021-01至2025-12,主要参与人
国家科技部重大项目,2021-12 至2026-11,主要参与人
任教课程 大学物理实验、基础物理与交叉学科前沿
招生方向 理论物理、凝聚态物理、生物物理、非平衡统计物理 荣誉奖励